enloquecer
/enlokeˈθeɾ/ · B1 · verb
to go crazy, to go nuts, to go insane, to go wild
en + loco + -ecer = to become loco, i.e. to go crazy
Built like enrojecer (to turn red): en- plus an adjective plus -ecer, meaning to become that thing. Loco means crazy, so enloquecer is to go crazy, or to drive someone else crazy.