desgracia
/desˈɡɾaθja/ · B1 · noun · f
shame
des- (un-) + gracia (grace, favour) = fallen out of grace → misfortune
Same build as English dis-grace, but Spanish leans on the luck sense: gracia is favour or good fortune, des- removes it. So desgracia is mostly misfortune or a mishap; por desgracia = unfortunately.