desesperado
/desespeˈɾado/ · B1 · adj
desperate
des- (un-) + esperado (hoped) = un-hoped, without hope
Spanish esperar means both to hope and to wait. Adding des- reverses it, like un- in English, so desesperado is someone whose hope has run out. It comes from the same Latin root, sperare, as English despair and desperate.