desafortunadamente
/desafoɾtuˌnadaˈmente/ · B1 · adv
unfortunately
des + afortunada + mente = un + fortunate + -ly
The Spanish prefix des- does the job of English un-, and -mente does the job of -ly, which turns an adjective into an adverb. The middle part, afortunada (fortunate), comes from fortuna (luck). It is built the same way as unfortunately, piece by piece.