desacuerdo
/desaˈkweɾdo/ · B2 · noun · m
disagreement
🙅♂️ des- (undo) + acuerdo (agreement) = un-agreement, so disagreement
Spanish des- reverses a word, like English dis- or un-. Acuerdo means agreement or accord, so desacuerdo is literally the undoing of an accord. Compare desorden (disorder) and desconfianza (distrust).